Claire de La Serre, Ph.D.

College of Family and Consumer Sciences

Foods and Nutrition

Assistant Professor

Address:
372 Dawson Hall
305 Sanford Dr.
Athens, GA 30602

E-Mail:

workOffice Phone: 706-542-4873

Curriculum Vitae

Current Classes

FDNS 2100E: Human Nutrition and Food

FDNS 4590/6590: Metabolism and Physiology of Food Intake, Energy Balance and Obesity

FDNS 8900: Seminar in Foods and Nutrition

Education

Degree Field of Study Institution Graduation
Ph.D Physiology and Nutrition AgroParisTech, France 2011
M.S. Life Sciences Engineering AgroParisTech, France 2008
M.S. Physiology and Nutrition AgroParisTech, France 2008

Research

Dr. de La Serre investigates the pathways by which diet composition affects energy balance. She is particularly interested in the influence of energy-dense diets on gut microbiota composition, gastrointestinal (GI) functions and inflammation. She studies how changes in microbiota composition can affect gut-brain signaling to promote overeating. Her laboratory uses animal models and studies phenomena from the behavioral aspect to the molecular pathway. For more information, see the Gastrointestinal Neurophysiology Laboratory.

Current Research

Current research projects include:

  • Influence of resistant starch on high-fat diet-induced inflammation and insulin resistance
  • Neuronal toxicity of bacterial products in energy-dense diet-induced obesity
  • Influence of microbiota composition on reward pathways and hedonic eating
  • Meal patterning and microbiota composition

Teaching

FDNS 2100E: Human Nutrition and Food

FDNS 4590/6590: Metabolism and Physiology of Food Intake, Energy Balance and Obesity

FDNS 8900: Seminar in Foods and Nutrition

Outreach

Dr. de La Serre is the seminar director for the department. She currently serves on the Graduate Committee, the Graduate Student Recruitment Committee and the Berdanier Undergraduate Research Award & CURO Committee.

Areas of Expertise

Microbiota, Gut epithelial functions, Inflammation, Gut-brain signaling, Feeding behavior, Satiety
 

Prior Professional Positions

Organization / Department Title Years of Service
University of Georgia, Foods and Nutrition Instructor 2012
Johns Hopkins University, School of Medicine, Psychiatry and Behavior Postdoctoral Research Fellow 2011-2012
University of California, Davis, School of Veterinary Medicine, Anatomy, Physiology and Cell Biology Exchange Scholar 2007-2010

Awards

Award Name Awarded By Year Awarded
Early Career Research Award College of Family and Consumer Sciences 2017
New Investigator Travel Award Society for the Study of Ingestive Behavior 2011

Journal Articles

 (*denotes UGA graduate student)

  • Pati S, Krishna S, Lee JH, Ross MK, de La Serre CB, Harn DH, Wagner JJ, Filipov  NM, Cummings BS. Effects of high-fat diet and age on the blood lipidome and circulating endocannabinoids of female C57BL/6 mice. BBA - Molecular and Cell Biology of Lipids (2017) 
  • Sen T, Cawthon C*, Ihde BT, Gawey BJ, Ahmed M, Long JA, Kirkland R, Hajnald A, DiLorenzo PM, de La Serre CB, Czaja K. Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity, Physiology and Behavior (2017)
  • Vaughn AC, Cooper EM, DiLorenzo PM, O'Loughlin LJ, Konkel ME, Peters JH, Hajnal A, Sen T, Lee SH*, de La Serre CB, Czaja K. Minocycline’s effects on diet-induced changes in gut microbiota and reorganization of gut-brain vagal communication, Acta Neurobiologiae Experimentalis (2017)
  • Li L, de La Serre CB, Zhang N, Hong L, Bi S. Dorsomedial hypothalamic neuropeptide Y modulate hepatic insulin sensitivity and glucose, Endocrinology (2016)  
  • de La Serre CB, Kim YJ, Moran TH, Bi S. Dorsomedial hypothalamic NPY affects cholecystokinin-induced satiety via modulation of brainstem catecholamine neuronal signaling, American Journal of Physiology --Regulatory, Integrative and Comparative Physiology (2016)
  • Krishna S, Lin Z, de La Serre CB, Wagner JJ, Harn DH, Pepples LM, Djani DM, Weber MT, Srivastava L, Filipov NM. Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake. Physiology and Behavior (2016)
  • Brown J*, Gregory C, de La Serre CB, Magnan N. Summer garden programs improve children’s food knowledge and preferences: evidence using stated and revealed preference measures. HortTechnology (2016)
  • Lee SH*, de La Serre CB. Gut microbiome-brain communications regulate host physiology and behavior the microbiota-gut-brain axis. Journal of Nutritional Health & Food Science (2015)
  • Dollé L, de La Serre CB, and van Grunsven LA. Are dietary emulsifiers making us fat? Journal of hepatology (2015)
  • Krishna S, Keralapuratha MM, Lina Z, Wagner JJ, de La Serre CB, Harn DA, Filipov NM. Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL/6 mice. Neurosciences (2015)
  • de La Serre CB, de Lartigue G, Raybould HE. Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. Physiology and Behavior (2015)
  • de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould HE, Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS ONE (2012)
  • de Lartigue G, de La Serre CB, Raybould HE. Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin. Physiology and Behavior (2011)
  • de Lartigue G, Barbier de La Serre C, Espero E, Lee J, Raybould, HE. Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. American Journal of Physiology - Endocrinology and Metabolism (2011).
  • de La Serre CB, Ellis CL, Lee J, Hartman AL, Rutledge JC, Raybould HE. Propensity to high fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. American Journal of Physiology - Gastrointestinal and Liver Physiology (2010). Selected for highlights in Physiology 2010, no. 5
  • de Lartigue G, Dimaline R, Varro A, Raybould H, de La Serre CB, Dockray GJ. Cocaine-and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons. Gastroenterology (2010)
  • Paulino G, Barbier de La Serre C, Knotts T, Oort PJ, Newman J, Adams S, et al. Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. American Journal of Physiology - Endocrinology and Metabolism (2009)

Editorial Appointments

Position Name of Journal Year(s)
Editorial board member Physiology and Behavior 2016 -
Editorial board member American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2017-

Service

Organization Title Year(s) Service Type
The Obesity Society 2016 Abstract Reviewer
The The Society for the Study of Ingestive Behavior 2016 Poster competition judge

Books

Book chapters

Barbier de La Serre, C. and Moran TH. Cholecystokinin and Satiety, Handbook of Biologically Active Peptides, Second Edition, Abba J. Kastin (ed), Elsevier – Academic Press, Amsterdam (2013)

Working Papers

  • Lee SH*, Keirsey K*, Kirkland R, Fischer JG, de La Serre CB. Blueberry supplementation improves gut microbiota, inflammatory profile and insulin signaling in high fat fed rats. The Journal of Nutrition In Review
  • Grunewald ZI*, Kirkland R, Lee SH, Ross M, de La Serre CB. Cannabinoid receptor type-1 partially mediates metabolic endotoxemia-induced inflammation and insulin resistance – In preparation
  • Grunewald ZI*, Shill DD, Mohr SM, Jenkins NT, de La Serre CB. Influence of metabolic endotoxemia and cannabinoid receptor type-1 on cardiovascular and perivascular adipose tissue phenotype in rats – In preparation