Joseph Kindler

Education

Research

Dr. Kindler's research focuses on identifying determinants of peak bone mass, notably with respect to diet and chronic disease. His lab uses several bone imaging methodologies for clinical and translational research studies, including high resolution peripheral quantitative computed tomography (HR-pQCT), peripheral quantitative computed tomography (pQCT), and dual-energy X-ray absorptiometry (DXA). Dr. Kindler is currently leading several clinical studies aimed at characterizing the influence of youth-onset type 2 diabetes on the growing skeleton. To learn more, visit the Nutrition and Skeletal Health Laboratory page.

Teaching

FDNS 4510/6510 - Nutrition Throughout the Lifecycle

FDNS 2100 - Human Nutrition and Food

Prior Professional Positions

Awards

Books

1. Lobene AJ, Stone MS, Kindler JM, Bailey RL, McCabe LD, McCabe GP, Weaver CM. Minerals, Mineral Ratios, and Bone. In: Weaver, Daly, and Bischoff-Ferrari, Eds., Nutritional Aspects of Osteoporosis 2017, ICS 1297-Proceedings of the International Symposium on Nutritional Aspects of Osteoporosis, Nov 30-Dec 1, 2017, Hong Kong.
2. Lewis RD, Kindler JM, Laing EM. Obesity, Insulin Resistance, and Pediatric Bone. In: Weaver, Daly, and Bischoff-Ferrari, Eds., Nutritional Aspects of Osteoporosis 2015, ICS 1297-Proceedings of the International Symposium on Nutritional Aspects of Osteoporosis, June 17-20, 2015, Montreal, CA.

Publications

ORIGINAL ARTICLES

1. Cousminer DL... Kindler JM... Zemel BS, Hankenson K, Grant SFA. Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping. Genome Biology. In Press. 

2. Kindler JM, Kelly A, Khoury PR, Levitt Katz LE, Urbina EM, Zemel BS. Bone mass and density in youth with type 2 diabetes, obesity, and healthy weight. 2020. Diabetes Care. In Press.

3. Kindler JM, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, McCormack S, Chese A, Cousminer DL, Mitchell JA, Winer KK, Grant SFA, Kalkwarf HJ, Zemel BS. Pediatric reference ranges for ultradistal radius bone density: results from the bone mineral density in childhood study. 2020. J Clin Endocrinol Metab. In Press.

4. Kindler JM, Laing EM, Liu W, Dain JE, Lewis RD. Pentosidine is associated with cortical bone geometry and insulin resistance in otherwise healthy children. J Bone Miner Res. 2019;34(8):1446-1450. PMID: 31220375.

5. Cousminer DL, McCormack SE, Chesi A, Mitchell JA, Kindler JM, Kelly A, Voigt BF, Kalkwarf HJ, Lappe JM, Shepherd JA, Oberfield SE, Gilsanz V, Zemel BS, Grant SFA. Postmenopausal osteoporotic fracture-associated COLIA1 variant impact bone accretion in girls. J Bone Miner Res. 2019;121:221-226. PMID: 30711642.

6. Kindler JM, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, McCormack S, Chesi A, Cousminer DL, Mitchell JA, Winer KK, Grant SFA, Kalkwarf HJ, Zemel BS. Characteristics of lumbar spine bone mineral apparent density in children: results from the bone mineral density in childhood study. J Clin Endocrinol Metab. 2019;104(4):1283-1292. PMID: 30265344.

7. Kindler JM, Vogel KA, Martin BR, McCabe LD, Henry MC, Peacock M, Warden SJ, McCabe GP, Weaver CM. Adiposity, insulin resistance, and bone mass in adolescents. J Clin Endocrinol and Metab.  2019;104(3):892-899. PMID:30312423.

8. Coheley LM, Kindler JM, Laing EM, Oshri A, Hill-Gallant KM, Warden SJ, Peacock M, Weaver CM, Lewis RD. Whole egg consumption and cortical bone in healthy children. Osteoporosis Int. 2018;29(8):1783-1791. PMID: 29713797. 

9. Kindler JM, Ross HL, Modlesky CM, Laing EM, Pollock NK, Singh H, Lewis RD. Obese versus normal-weight late-adolescent females have lower trabecular bone microarchitecture: a pilot case control study. Calc Tiss Int. 2017;101(5):479-488. PMID: 28710506.

10. Lobene AJ, Kindler JM, Pollock NK, Laing EM, Lewis RD. Zinc supplementation does not alter indicators of insulin secretion and sensitivity in black and white female adolescents. J Nutr. 2017;147(7):1296-1300. PMID: 28592518.

11. Kindler JM, Pollock NK, Laing EM, Oshri A, Jenkins NT, Isales CA, Hamrick MW, Ding K, Hausman DB, McCabe GP, Martin B, Hill-Gallant KM, Warden SJ, Weaver CM, Peacock M, Lewis RD. Insulin resistance and the IGF-1–cortical bone relationship in children ages 9-13 years. J Bone Miner Res. 2017;32(7):1537-1545. PMID: 28300329.

12. Giudici KV, Kindler JM, Martin BR, Laing EM, McCabe GP, McCabe LD, Hausman DB, Martini LA, Lewis RD, Weaver CM, Peacock M, Hill Gallant KM. Associations among osteocalcin, leptin and metabolic health in children ages 9-13 years in the United States. Nutr Metab (Lond). 2017;14:25. PMID: 28286536.

13. Kindler JM, Pollock NK, Laing EM, Jenkins NT, Oshri A, Isales C, Hamrick MW, Lewis RD. Insulin resistance negatively influences the muscle-dependent IGF-1-bone mass relationship in premenarcheal girls. J Clin Endocrinol Metab. 2016;101(1):199-205. PMID: 26574958.

14. Kindler JM, Goff HL, Laing EM, Modlesky CM, Pollock NK, Baile CA, Lewis RD. Load specific physical activity scores are related to tibia bone architecture. Int J Sport Nutr Exerc Metab. 2015;25(2):136-144. PMID: 25029040.

15. Reed JL, De Souza MJ, Kindler JM, Williams NI. Nutritional practices associated with low energy availability in Division I female soccer players. J Sports Sci. 2014;32(16):1499-1509. PMID: 24787233.

REVIEW ARTICLES and META ANALYSES

1. Fedewa MV, Bentley JL, Higgins S, Kindler JM, Esco MR, MacDonald HV. Celiac disease and bone health in children and adolescents: a systematic review and meta-analysis. J Clin Densitom. 2019. Epub ahead of print. PMID: 30833087.

2. Kindler JM, Lewis RD, Hamrick MW. Skeletal muscle and pediatric bone development. Curr Opin Endocrinol Diabetes Obes. 2015;22(6):467-474. PMID: 26414082.

Working Papers

MANUSCRIPTS in REVIEW

Kindler JM, Khoury PR, Urbina EM, Zemel BS. Diet Quality and Bone Density in Youth with Healthy Weight, Obesity, and Type 2 Diabetes. In Progress. 

Kindler JM, Xang D, Satler L, Ishikawa Y, Gallo S. Bone Density and Lean Mass in Youth with Pre-Diabetes vs. Normal Glucose Control. Calcified Tiss Int. In Review.

Higgins S, Zemel BS, Khoury PR, Urbina EM, Kindler JM. Abdominal visceral fat assessed via DXA and arterial stiffness in youth with healthy weight, obesity, and type 2 diabetes. Ped Obesity. In Review. 

Zysman-Colmar Z, Munsar Z, Kindler JM, Stallings V, Zemel BS, Kelly A. An analysis of height adjustment methods for bone mineral density in youth with CF. Journal of Cystic Fibrosis. In Review.

Kindler JM, Guo M, Baker J, McCormack S, Armenian S, Zemel B, Leonard M, Mostoufi-Moab S. Musculoskeletal deficits in pediatric, adolescent, and young adult survivors of allgeneic hematopoietic stem cell transplantation. J Bone Miner Res. In Review. 

MANUSCRIPTS in PROGRESS

Lei WS, Kilberg M, Kelly A, Kindler JM. Acute changes in bone metabolism following glucose consumption involve incretin and metabolic hormones in youth with cystic fibrosis. In Progress.

Lance J, Zemel BS, Urbina EM, Kindler JM. Non-Linear Associations between BMI and Bone Density in Youth with Extreme Obesity. 

Vajravelu ME, Kindler JM, Zemel B, Jawad A, Koren D, Brar P, Brooks L, Reiner J, Levitt Katz LE. Visceral adiposity in obese adolescents is related to insulin sensitivity, overnight oxygen saturation and inflammation. 

Welch ES, Zhang C, Kindler JM, McCully KK. Evaluation of Cortical Bone Metabolism using Near-Infrared Spectrospcopy in Healthy Adults.