171 Dawson Hall
305 Sanford Dr.
Athens, GA 30602
workOffice Phone: 716-534-0626
|Degree||Field of Study||Institution||Graduation|
|Bachelor of Science||Biochemistry||SUNY College of Environmental Science and Forestry||2014|
Michael is conducting nutrigenomics research in the Micronutrient Proteomic Research Laboratory under the direction of Dr. Grider.
The human transcription factor metal response element (MRE)-binding transcription factor 1 (MTF-1) binds to the DNA motif called the MRE in the promoter region of genes to regulate their transcriptional expression. MTF-1 is a zinc activated (zinc finger) protein whose activity and migration to the nucleus of cells is directly altered by levels of dietary zinc ingestion. MTF-1 can alter the gene expression of proteins, but we are currently looking at the fluctuation in levels of non-coding microRNAs (miRNAs), which themselves change gene expression post-transcriptionally. And some miRNA can also affect MTF-1 expression. Therefore there are cascading regulatory effects involving MTF-1 and miRNAs which can be initiated by zinc.
Instructor of Record, GRSC 7770: Fall 2018
TA, FDNS 2100: Fall 2017, Spring 2018
Georgia Science and Engineering Fair, Junior Division Category Leader, 2018
350.org: Student Leader, 2012-2014
Syracuse Animal Rights Organization: Member, 2012-2014
Syracuse Peace Council: Intern, 2013
|Award Name||Awarded By||Year Awarded|
|Marian Wang Nutrition Scholarship||UGA College of Family and Consumer Sciences||2018|
|Virgina Wilbanks Kilgore Scholarship||UGA College of Family and Consumer Sciences||2017|
|Graduated Magna Cum Laude||SUNY College of Environmental Science and Forestry||2014|
Francis M, Grider A (2018) Bioinformatic analysis of the metal response element and zinc-dependent gene regulation via the metal response element-binding transcription factor 1 in Caco-2 cells. BioMetals.
Francis, M, Grider, A. (2018) Combined regulation of MTF-1 and miRNA in human osteogenic pathways: genome-wide in silico target identification. Manuscript in preparation.
Grider, A, Francis, M. (2018) The zinc transcriptional regulatory element within the human genome: quantity and location upstream from microRNA genes. Manuscript in preparation.
Francis, M, Grider, A. In silico secondary analysis of the metal regulatory element/MTF-1 within the human genome: relation to zinc-responsive genes [abstract]. In: Current Developments in Nutrition; 2018 June 9-12; Boston, MA. ASN; 2018.
Francis, M, Grider, A. The proximity of the metal regulatory element to microRNA genes within the human genome: in silico analysis [abstract]. In: Current Developments in Nutrition; 2018 June 9-12; Boston, MA. ASN; 2018.
Dr. Arthur Grider, Dr. Hea Jin Park, Dr. Chad Paton, Dr. Robert Pazdro, Dr. Magdy Alabady