Chad Michael Paton
College of Family and Consumer Sciences
|Degree||Field of Study||Institution||Graduation|
|Postdoc||University of Wisconsin-Madison||2010|
|Postdoc||Blood Research Institute||2007|
|PhD||University of Maryland-College Park||2005|
|BS/MS||Michigan State University||2000/2002|
My research is focused on the bioactive properties of two specific lipids: Dihydrosterculic acid (DHSA) and linoleic acid. DHSA is a cyclopropene fatty acid that is found naturally in cottonseed oil and it blocks endogenous lipid synthesis and cholesterol biogenesis. I am actively pursuing methods to assess its ability to treat hyperlipidemia and hypercholesterolemia in animal and human models. My work in the bioactive properties of linoleic acid has centered on its role in modulating skeletal muscle myogenesis and mitochondrial biogenesis. As a long-chain omega-6 polyunsaturated fatty acid, it promotes transcriptional activity via nuclear receptor-DNA interactions and more recently I have found that its ability to induce angiopoietin-like protein 4 production in muscle significantly impairs the capacity for muscle differentiation and metabolic function. The purpose of my research is to help restore normal metabolic function in disease states using molecular biology and biochemistry to understand how macronutrient metabolism is regulated in cell and animal models. For more information, visit the Biochemistry of Metabolism Laboratory.
Yura Son & Chad M. Paton, Chapter 18 - Lipid metabolic features of skeletal muscle in pathological and physiological conditions. Lipid Signaling and Metabolism, Academic Press, 2020, Pages 359-383, ISBN 9780128194041, https://doi.org/10.1016/B978-0-12-819404-1.00018-X
FDST 4070/6070 - Nutritional Quality
FDST/FDNS 8150- Food and Nutritional Biochemistry
FDST 7030E- Food Biochemical Reactions
- PUFA-mediated regulation of myogenesis.
- The role of dihydrosterculic acid in hepatic lipid metabolism.
(*Denotes a student for which I am/was the major professor)
- Guarneiri LL, Paton CM, Cooper JA. Pecan-enriched diets alter cholesterol profiles and triglycerides in adults at-risk for cardiovascular disease in a randomized, controlled trial. J Nutr. 2021 Aug 12:nxab248. doi: 10.1093/jn/nxab248.
- Guarneiri LL, Paton CM, Cooper JA. Pecan-enriched diets decrease postprandial lipid peroxidation and increase total antioxidant capacity in adults at-risk for cardiovascular disease. In Press: Nutrition Research.
- Guarneiri LL, *Spaulding M, Marquardt AR, Cooper JA, Paton CM. Angiopoietin-like protein-3 and -4 responses to tree nut-enriched meals in healthy adults: A secondary analysis of randomized trials. Nutr Res. 2021 Jun 12;92:62-71. doi: 10.1016/j.nutres.2021.06.001.
- *Lewandowski KR, *Xhang X, Hayes M, Ferruzzi MG, Paton CM. Design and Nutrient Analysis of a Carotenoid-Rich Food Product to Address Vitamin A and Protein Deficiency. Foods. 2021 May 7;10(5):1019. doi: 10.3390/foods10051019
- Lin YJ, Qin Z, Paton CM, Fox DM, Kong F. Influence of cellulose nanocrystals (CNC) on permeation through intestinal monolayer and mucus model in vitro. Carbohydr Polym. 2021 Jul 1;263:117984. doi: 10.1016/j.carbpol.2021.117984. Epub 2021 Mar 24.
- Paton CM, *Son Y, Vaughan RA, Cooper JA. Free Fatty Acid-Induced Peptide YY Expression Is Dependent on TG Synthesis Rate and Xbp1 Splicing. Int. J. Mol. Sci. 2020, 21(9), 3368; doi:10.3390/ijms21093368.
- Knudsen KH, Stanya KJ, Hyde AL, Chalom MM, Alexander RK, Liou YH, Gangl MR, Jacobi D, Liu S, Sopariwala DH, Fonseca-Pereira D, Li J, Hu FB, Garrett WS, Narkar V, Ortlund EA Kim JH, Paton CM, Cooper JA, Lee CH. Interleukin 13 drives metabolic conditioning of muscle to endurance exercise. Science. 2020 May 1;368(6490).
- *Son Y, *Cox JM, Stevenson JL, Cooper JA, Paton CM. Angiopoietin-1 Protects 3T3-L1 Pre-Adipocytes from Saturated Fatty Acid-Induced Cell Death. Nutr Res. 2020 Feb 13;76:20-28. doi: 10.1016/j.nutres.2020.02.007.
- *Zhang X, Cavender GA, *Lewandowski KR, Cox GO, Paton CM. Sensory Analysis of a Processed Food Intended for Vitamin A Supplementation. Foods. 2020 Feb 21;9(2). pii: E232. doi: 10.3390/foods9020232.
- Rodrigues L, Cooper JA, Paton CM. Acute Consumption of Black Walnuts Increases Fullness and Decreases Lipid Peroxidation in Humans. Nutr Res. 2019 Nov;71:56-64. doi: 10.1016/j.nutres.2019.09.002. Epub 2019 Sep 9.
- Marquardt AR, *Lewandowski KR, Paton CM, Cooper JA. Comparison of metabolic and antioxidant responses to a breakfast meal with and without pecans. Journal of Functional Foods 62 (2019) 1035592. doi.org/10.1016/j.jff.2019.103559.
- Kaviani S, *Taylor CM, Stevenson JA, Cooper JA, Paton CM. A 7-day high-PUFA diet reduces angiopoietin-like 3 and 8 responses and postprandial triglyceride levels in healthy females but not males. BMC Nutrition 2019 5:1. doi.org/10.1186/s40795-018-0262-7.
- Polley KR, Kamal F, Paton CM, Cooper JA. Appetite Responses to High-Fat Diets Rich in Mono-unsaturated versus Poly-unsaturated Fats. Appetite. 2019 Mar 1;134:172-181.
- Polley KR, Oswell NJ, Pegg RB, Paton CM, Cooper JA. A 5-day high-fat diet rich in cottonseed oil improves cholesterol profiles and triglycerides compared to olive oil in healthy men. Nutr Res. 2018 Dec;60:43-53.
- Coughlin AM, Nagelkirk PR, Cooper JA, Paton CM, Friderici KH, Wingerd BA, Pivarnik JM, Womack CJ. The Influence of Tissue Plasminogen Activator I/D Polymorphism on the tPA Response to Exercise. Int J Exerc Sci. 2018 Oct 1;11(3):1136-1144. eCollection 2018.
- Polley KR, Miller MK, Johnson M, Vaughan R, Paton CM, Cooper JA. Metabolic responses to high-fat diets rich in MUFA v. PUFA. Br J Nutr. 2018 Jul;120(1):13-22.
- Paton CM, Vaughan RA, Alpergin ES, Assadi-Porter F, Dowd MK. Dihydrosterculic acid from cottonseed oil suppresses desaturase activity and improves liver metabolomic profiles of high fat fed mice. Nutr Res. 2017 Sep;45:52-62. Epub 2017 Jul 4.
- Stevenson JL, Paton CM, Cooper JA. Hunger and satiety responses to high-fat meals after a high polyunsaturated fat diet. Nutrition. 2017 Sep;41:14-23. doi: 10.1016/j.nut.2017.03.008. Epub 2017 Mar 29. Impact Factor: 3.4
- Krishnan S, Steffen L, Paton CM, Cooper JA. Impact of dietary fat composition on prediabetes – a 12-year follow up study. Public Health Nutr. 2017 Jan 31:1-10. Impact Factor: 2.3
- Stevenson JL, Miller MK, Skillman HE, Paton CM, Cooper JA. A PUFA-rich diet improves fat oxidation following saturated fat-rich meal. Eur J Nutr. 2017 Aug;56(5):1845-1857. Epub 2016 May 12. Impact Factor: 4.3
- *Stamatikos AD, da Silva RP, Lewis JT, Douglas DN, Kneteman NM, Jacobs RL, and Paton CM. Tissue specific effects of dietary carbohydrates and obesity on ChREBPα and ChREBPβ expression. Lipids. 2016 Jan;51(1):95-104. Impact Factor: 1.9
- *Kang M, Vaughan RA, Paton CM. Fibrin degradation fragment-E induces adipocyte inflammation and suppresses insulin-stimulated glucose disposal in vitro. Am J Physiol Cell Physiol. 2015 Dec 1;309(11):C767-74. Impact Factor: 3.4
- Vaughan RA, *Garrison RL, *Stamatikos AD, *Kang M, Cooper JA, and Paton CM. A high linoleic acid diet does not induce inflammation in mouse liver or adipose tissue. Lipids 2015 Nov;50(11):1115-22. Impact Factor: 1.9
- Chang H, Kozimor AL, Paton CM, and Cooper JA. Acute effect of dietary fatty acid composition on postprandial metabolism in women. Exp Physiol. 2014 Sep;99(9):1182-90. Impact Factor: 2.7
- *Stamatikos AD & Paton CM. Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism. Am J Physiol Endocrinol Metab. 2013 Oct;305(7):E767-E775. Impact Factor: 4.1
- *Rogowski MP, Flowers MT, *Stamatikos AD, Ntambi JM, Paton CM. SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARδ expression in mice. J Lipid Res. 2013 Oct;54(10):2636-46. Impact Factor: 4.7
- Cooper JA, Manini T, Paton CM, Yamada Y, Everhart JE, Cummings S, Mackey DC, Newman AB, Glynn NW, Tylavsky F, Harris T, and Schoeller DA. Longitudinal change in energy expenditure and effects on energy requirements of the elderly. Nutr J. 2013 Jun 6;12(1):73. Impact Factor: 2.6
- Paton CM, *Rogowski MP, Kozimor AL, Stevenson JL, Chang H, Cooper JA. Lipocalin-2 increases fat oxidation in vitro and is correlated with energy expenditure in normal weight but not obese women. Obesity. 2013 Dec;21(12):E640-8. Impact Factor: 4.4
- Flowers MT†, Paton CM†, O’Byrne SM, Schiesser KJ, Dawson, J, Blanner WS, Kendziorski C, Ntambi JM. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. PLoS One 2011 May 9;6(5):e19734 . (†Authors contributed equally). Impact Factor: 4.1
- Cooper JA, Watras AC, Paton CM, Wegner FH, Adams AK, Schoeller DA. Impact of Exercise and Dietary Fatty Acid Composition from a High-fat Diet on Markers of Hunger and Satiety. Appetite 2011 Feb;56(1):171-8. Impact Factor: 2.6
- Paton CM and Ntambi JM. Loss of stearoyl-CoA desaturase activity promotes ER stress induced Xbp-1 splicing and increases free cholesterol synthesis. Am J Physiol Endocrinol Metab (October 5, 2010). Impact Factor: 4.7
- Liu X, Miyazaki M, Flowers MT, Sampath H, Zhao M, Chu K, Paton CM, and Ntambi JM. Loss of Stearoyl-CoA desaturase-1 attenuates adipose inflammation: distinct roles of adipocyte-derived lipoprotein lipase and oleate. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):31-8. Epub 2009 Nov 12. Impact Factor: 7.2
- Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM. Skin-specific deletion of Stearoyl-CoA Desaturase-1 alters skin lipid composition and protects mice from high-fat diet induced obesity. Journal of Biological Chemistry. 2009 Jul 24;284(30):19961-73. Impact Factor: 5.3
- Paton CM & Ntambi JM. Biochemical and Physiological Function of Stearoyl-CoA Desaturase. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E28-37. Epub 2008 Dec 9. Impact Factor: 4.4