Emily E. Noble

College of Family and Consumer Sciences

Nutritional Sciences

Associate Professor


Degree Field of Study Institution Graduation
PhD Nutrition University of Minnesota 2014
MS Nutrition University of Minnesota 2010
BA Natural Science Hampshire College 2001


Dr. Noble's research uses animal models to investigate how the brain controls feeding behavior and energy balance. Our research also investigates the mechanisms by which nutrition affects the brain and cognitive function. Visit the Nutritional Neuroscience Laboratory or noblelab-uga.com/ to learn more.


Nutrition and Neuroscience FDNS 8240

Food and Nutritional Biochemistry FDNS/FDST 8150

Introduction to Foods and Nutrition FDNS 2100

Prior Professional Positions

Organization Title Years of Service
University of Southern California Postdoctoral Researcher 4
University of California, Los Angeles Postdoctoral Researcher 1


Award Name Awarded By Year Awarded
Rolls-Simons Travel Award The Obesity Society 2019
Ethan Sims Young Investigator Award The Obesity Society 2017
Early Career Grant Challenge Award The Obesity Society 2017
Harry R. Kissileff Award for best oral presentation The Society for the Study of Ingestive Behavior 2017
Oral presentation award (2nd place) The Diabetes and Obesity Research Institute 2017
Young Investigator Travel Award Winter Conference on Brain Research 2017
New Investigator Travel Award Society for the Study of Ingestive Behavior 2016
WISE Travel Award Women in Science and Engineering, USC 2015


Organization Title Year(s) Service Type
The Obesity Society Program Committee- Track 2 Co-Chair 2021
Society for the Study of Ingestive Behavior Public Communications Committee 2019
The Obesity Society Abstract review 2017-2019
Mouse Metabolic Phenotyping Centers grant program Reviewer 2019
Society for the Study of Ingestive Behavior New Investigator Advisory Board 2018-2019

Current Research

Current research topics in include:

Neuropeptides and the regulation of eating behavior 

Brain glycogen and body weight regulation

Western dietary factors and cognitive function

The impact of early life nutrition on brain development and behavior

Journal Articles

* Indicates co-corresponding

Liu CM., Spaulding M., Rea JJ., Noble EE.*, and Kanoski SE.*, “Oxytocin and food intake control: neural, behavioral, and signaling mechanisms” IJMS, 2021; Accepted Oct 2021

Tsan L., Sun S., Hayes AMR., Bridi L., Chirala L., Noble EE., Fodor, A., and Kanoski SE., “Early life Western diet-induced memory impairments and gut microbiome changes in female rats are long lasting despite healthy dietary intervention.” Nutritional Neuroscience, 2021; Sept 27; 1-17 PMID: 34565305

Noble EE., Olson, CA., Davis E., Tsan, L., Chen YW., Schade R., Liu CM., Suarez AN., Jones RB., de La Serre, C., Yang X., Hsiao EY., and Kanoski SE. “Gut microbial taxa elevated by dietary sugar disrupt memory function” Translational Psychiatry, 2021; Mar 31; 11(1):194 PMID: 33790226

Tsan, L., Decarie-Spain, L., Noble EE.*, Kanoski SE.* “Western diet consumption during development: setting the stage for neurocognitive dysfunction” Frontiers in Neuroscience 2021; 15:632312, PMID 33642988

Lord, MN., Subramanian K., *Kanoski SE., *Noble EE. “Melanin-concentrating hormone and food intake control: neural pathways and mechanisms” Peptides 2020; epub ahead of print; PMID: 33370567

Reed DR., Alhadeff AL., Beauchamp GK., Chaudhari N., Duffy VB., Dus M., Fontanini A., Glendinning JI., Green BG., Joseph PV., Kyriazis GA., Lyte M., Maruvada P., McGann JP., McLaughlin JT., Moran TH., Murphy C., Noble EE., Pepino MY., Pluznick JL., Rother KI., Saez E., Spector AC., Sternini C., and Mattes RD., "Perspective: Sensory Nutrition and Disease." American Journal of Clinical Nutrition 2020; epub ahead of print PMID 33300030

Terrill SJ., Subramanian K., Lan R. Liu CM., Cortella AM., *Kanoski SK., *Noble EE.  Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner” Neuropharmacology 2020 Nov 1; 178:108270; PMID 32795460

Liu CM., Davis, EA., Suarez, AS., Wood RI., *Kanoski SE, *Noble EE., “Sex differences and estrous influences on oxytocin control of food intake” Neuroscience 2020; Nov 1; 447:63-73; PMID 31738883

Liu CM., Hsu TM., Suarez AN., Subramanian KS., Fatemi RA., Cortella AM., Noble EE., Roitman MF., Kanoski SE. “Central oxytocin signaling inhibits food reward-motivated behaviors and VTA dopamine responses to food-predictive cues” Hormones and Behavior 2020 Oct 1; 126:104885; PMID 32991888

Suarez AN., Liu CM., Cortella AM., Noble EE., Kanoski SE. “Ghrelin and orexin interact to increase meal size through a descending hippocampus to hindbrain signaling pathway” Biol Psychiatry 2020 Jun 1; 87(11): 1001-1011; PMID 31836175

Noble EE., Wang Z., Liu CM., Davis EA., Suarez AN., Stein LM., Tsan L., Terrill SJ., Hsu TM., Jung A., Raycraft LM., Hahn JD., Darvas M., Cortella AM., Schier LA., Johnson AW., Hayes MR., Holschneider DP., Kanoski SE. “Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormoneNature Communications 2019; 10(1):4923; PMID 31664021

Suarez A., Noble EE., Kanoski S. “Regulation of memory by feeding-relevant biological systems: following the breadcrumbs to the hippocampus” Frontiers in Molecular Neuroscience 2019; 12:101 PMID 31057368

Noble EE., Hsu TM., Liang J., Kanoski SE. “Early life sugar consumption has long-term negative effects on memory function in Male rats” Nutritional Neuroscience 2017; 1-11; PMID 28944721

Malaeb S., Perez-Leighton CE., Noble EE., Billington C. “A ‘NEAT’ approach to obesity prevention in the modern work environment” Workplace Health Saf. 2019; 67(3): 102-110; PMID: 30370831

Ying Z., Byun H., Meng Q., Noble EE., Zhang G., Yang X., Gomez-Pinilla F. “The biglycan gene connects metabolic dysfunction with brain disorder” Biochim Biophys Acta. 2018 1864(12):3679-87; PMID: 30291886

Noble EE., Hahn JD., Konanur VR., Hsu TM., Page SJ., Cortella AM., Liu CM., Song MY., Suarez AN., Szujewski CC., Rider D., Clarke JE., Darvas M., Appleyard SM., Kanoski, SE. “Control of feeding behavior by cerebral ventricular volume transmission of melanin-concentrating hormone” Cell Metabolism 2018; PMID 29861386 Featured on the cover

Suarez AN., Hsu TM., Liu CM., Noble EE., Cortella AM., Nakamoto EM., Hahn JD., de Lartigue G., Kanoski SE. “Gut vagal sensory signaling regulates hippocampus function through multisynaptic pathways” Nature Communications 2018; PMID 29872139

Hsu TM., Noble EE., Reiner DJ., Liu CM., Suarez AN., Konanur VR., Hayes MR., Kanoski SE. “Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference” Neuropharmacology 2018; 131:487-96; PMID 29191751

Reiner DJ., Mietlicki-Baase EG., Olivos DR., McGrath LE., Zimmer DJ., Koch-Laskowski K., Krawczyk J., Turner CA., Noble EE., Hahn JD., Schmidt HD., Kanoski SE., Hayes MR. “Amylin acts in the lateral dorsal tegmental nucleus to regulate energy balance through gamma-aminobutyric acid signalling” Biological Psychiatry 2017; 82(11):828-838; PMID 28237459 Featured on the cover

Lopez-Ferreras L., Richard JE., Noble EE., Eerola K., Anderberg RH., Olandersson K., Tiang L., Kanoski SE., Hayes MR., Skibicka KP. “Lateral hypothalamic GLP-1R receptors are critical for the control of food reinforcement, ingestive behavior and body weight” Molecular Psychiatry 2017; PMID 28894301

Hsu, TM., Noble EE., Liu CM., Cortella AM., Konanur VR., Suarez AN., Reiner DJ., Hahn JD., Hayes MR., Kanoski SE. “A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signalling” Molecular Psychiatry 2017; PMID 28461695

Noble EE., Hsu, TM., Kanoski SE. “Gut to brain dysbiosis: Mechanisms linking Western Diet consumption, the microbiome, and cognitive impairment” Frontiers in Behavioral Neuroscience. 2017; 11:9; PMID 28194099

Noble EE., Hsu TM., Jones RB., Fodor AA., Goran MI., Kanoski SE. “Early life sugar consumption affects the rat microbiome independently of obesity” Journal of Nutrition 2017; 147(1): 20-8; PMID 27903830

Noble E.E. and Kanoski S.E. “Early life exposure to obesogenic diets and learning and memory dysfunction” Curr Opin Behav Sci 2016; 9:7-14; PMID 26858972

Meng Q., Ying Z., Noble E. Zhao Y., Agrawal R., Mikhail A., Zhuang Y., Tyagi E., Zhang Q., Lee J., Morselli M., Orozco L., Guo W., Kilts T., Zhu J., Zhang B., Pellegrini M., Xiao X., Young M., Gomez-Pinilla F., Yang, X. “Systems nutrigenomics reveals brain gene networks linking metabolic and brain disorders” eBioMedicine 2016; 7:157-66; PMID: 27322469

Agrawal R., Zhuang Y., Noble E.E., Vergnes L., Ying Z., Reue K., Gomez-Pinilla F. “Dietary fructose aggravates the pathobiology of TBI by influencing energy homeostasis and plasticity” J Cereb Blood Flow Metab. 2016; PMID: 26661172.

Teske JA., Perez-Leighton CE., Noble EE., Wang C., Billington CJ., Kotz CM. “Effect of housing types on growth, feeding, physical activity, and anxiety-like behavior in male Sprague-Dawley rats” Front Nutr 2016;3:4; PMID: 26870735

Hsu TM., Hahn, JD., Konanur VR., Noble EE., Suarez AN., Thai J., Nakamoto EM., Kanoski SE. “Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways” Elife 2015; 4; PMID: 26745307

Agrawal R., Noble E., Tyagi E., Zhuang Y., Ying Z., Gomez-Pinilla F. “Flavonoid Derivative 7,8-DHF attenuates TBI pathology via TrkB activation” Biochim Biophys Acta. 2015; 1852 (5): 862-72; PMID 25661191

Wu A., Noble EE., Tyagi E., Ying Z., Zhuang Y., Gomez-Pinilla F. “Curcumin boosts DHA in the brain: implications for the prevention of anxiety disorders” Biochim Biophys Acta. 2015; 1852(5): 951-61; PMID 25550171

Noble EE., Mavanji V., Little MR., Kotz CM., Billington CJ., Wang, C. “Exercise reduces diet-induced cognitive decline and increases hippocampal brain-derived neurotrophic factor in CA3 neurons” Neurobiology of Learning and Memory 2014; 114C: 40-50; PMID 24755094

Noble EE., Little MR., Billington CJ., Kotz CM., Wang CF. “Oxytocin in the ventromedial hypothalamus reduces feeding and body weight in Sprague Dawley rats” Am J Physiol Regul Integr Comp Physiol. 2013; 307 (6): R737-45; PMID 24990860

Noble EE., Billington CJ., Kotz CM., Wang C. “The lighter side of BDNF” Am J Physiol Regul Integr Comp Physiol 2011; 300: R1053-1069; PMID 21346243

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